Laminar flame speed of a fuel/oxidizer mixture has been extensively studied in combustion research and widely used as target responses for the development, validation, and optimization of a detailed reaction mechanism because it is indicative of the reactivity, the diffusivity, and the exothermicity of the given mixture. In many combustion applications, such as in engines and gas turbines, flame speeds play a significant role in their performance and emissions. Ozone (O3) has been shown to have positive effects on flame stabilization and flame speed enhancement. Although plasma is attractive to combustion society, plasma-assisted combustion still faces great challenges due to the fact that most combustion systems operate at high-pressure conditions, while high-pressure environment does not favor plasma production. However, plasma is effective in ozone production and the long lifetime of ozone has the advantage of enhancing fuel oxidation.